WSU to Study Iraq Toxins' Effect
Spokesman-Review
by Bert Caldwell
Research to examine how exposure might damage offspring of soldiers
Washington State University scientists will use a $1.7 million grant to study what multi-generation genetic damage might be done by toxins U.S. troops could encounter in Iraq.
The research using laboratory rats, not humans, will be the first for the military to examine the epigenetic effects of pesticides, herbicides and other compounds, said lead scientist Michael Skinner, director of the university's Center for Reproductive Biology.
Previous studies have looked at the health effects of other substances, notably the Agent Orange used to defoliate jungles in Vietnam, on the soldiers directly exposed, he said, not on their children or grandchildren.
"The science really had not caught up with the trans-generational stuff," said Skinner, one of several WSU pioneers in the field of epigenetic, or multi-generational, inheritance.
Besides herbicides and pesticides – which and in what combinations has not been determined – the study also will look at the effects of explosives residues, he said.
The four-year study will allow researchers to see how any changes in genetic chemistry that develop are passed along through two subsequent generations of rats, he said, noting that only the first two years of research have been funded.
Among the problems that might develop are kidney disease, or changes in the male and female reproductive organs, he said.
If any genetic markers are identified in rats, Skinner said, follow-up research could look at whether they might show up among members of the military as well.
That would be of particular interest to Dave Holmes, interim chief operating officer of the Institute for Systems Medicine, which was awarded the U.S. Department of Defense grant passed through to Skinner.
Holmes' son, Tim Hammond, did two tours in Iraq with the U.S. Marine Corps.
"They sprayed all kinds of stuff on them," Holmes said.
Although the grant money, the first awarded ISM, will fund work in Pullman, he said the organization's supporters hope any subsequent clinical studies will be done in Spokane.
"There's a lot of excitement about making it happen," he said.





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VA to automate its Agent Orange claims process
WASHINGTON — The Department of Veterans Affairs plans to announce today that it will fully automate how it pays claims for illnesses related to exposure to the chemical Agent Orange to keep an overburdened system from collapse.
It is the department's first effort at automating claims processing in its 80-year history, says VA chief technology officer Peter Levin. It comes as the agency struggles to cut a backlog of more than 1 million disability claims, appeals and other cases.
The system "is likely to break" if nothing is done, Levin says.
"Look, the bottom line is why the hell they didn't do (automation) 30 years ago," says John Rowan, national president of Vietnam Veterans of America. "The question is whether they will do it right."
VA Secretary Eric Shinseki took office last year and said no disability claim should take longer than four months to process. However, department records show that almost 40% take an average of 161 days to process and that will increase to 190 days without automation.
The increase is largely the result of Shinseki's efforts to allow more Agent Orange disability claims.
The military used Agent Orange to defoliate plants and trees in which Vietnamese insurgents hid during the Vietnam War. It was later shown to cause cancer, birth defects and other ailments. After years of debate and medical research, the VA began compensating veterans for illnesses linked to Agent Orange with non-taxable, monthly payments to those without dependents ranging from $123 to $2,673.
In October, Shinseki added three more illness to those linked to the herbicide: Parkinson's disease, B-cell leukemia and heart disease. He told Congress this would generate another 228,000 claims in the next two years.
The automated claims system will apply only to veterans filing these new Agent Orange claims. If it works, the VA hopes to expand automated claims processing through the department, says Roger Baker, an assistant secretary for information and technology.
Shinseki said in a statement that veterans harmed during military service deserve the "best this nation has to offer."
Old, incomplete or complicated records have hampered the VA's move to automation, says former VA secretary James Peake, who applauded Shinseki's move. Many records require hands-on investigation, says Peake, who led the department from 2007 to 2009.
Agent Orange cases, however, may be a good place to start, Peake says. Once the information from a veteran's discharge papers is entered into a computer, the VA can quickly verify service in Vietnam in many cases — a key factor in determining eligibility for Agent Orange benefits.

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